The Senate lists rejected and withdrawn Cabinet nominations. At the bottom of this page are the seven that have failed during the past 30 years, and I add the reasons for the failure. All involved questions of about ethics or personal misconduct. (Kerik later went to prison on other charges.)
The list shows that the last four presidents -- George H.W. Bush, Bill Clinton, George W. Bush, and Barack Obama all lost a nominee in their first couple of months in office.
It seems very likely that Labor nominee Andrew Pudzer will be the latest entry.
Manu Raju reports at CNN:
Top Senate Republicans have urged the White House to withdraw the Andrew Puzder nomination for labor secretary, a senior GOP source said, adding there are four firm Republican no votes and possibly up to 12.
Puzder needs at least 50 votes to pass with the tie-breaking vote of Vice President Mike Pence, and Republicans only hold control of 52 seats.
Puzder, the CEO of the company that owns the Hardee's and Carl's Jr. fast food chains, has faced fierce opposition mostly from Democrats in part related to his position on labor issues as well as the fact that he employed an undocumented housekeeper.
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Name: John G. Tower
Nominated by: George Bush
Nomination Position: Defense
Date Nominated: January 20, 1989
Date Rejected: March 9, 1989 Vote: 47-53
Reasons: drinking, conduct toward women, financial conflicts
Name: Zoe E. Baird
Nominated by: William J. Clinton
Nomination Position: Attorney General
Date Nominated: January 21, 1993
Date Withdrawn: January 26, 1993
Reason: Undocumented household employee
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Name: Anthony Lake
Nominated by: William J. Clinton
Nomination Position: Director, CIA
Date Nominated: January 9, 1997
Date Withdrawn: April 18, 1997
Reasons: policy disputes, financial issues
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Name: Hershel W. Gober
Nominated by: William J. Clinton
Nomination Position: Veterans Affairs
Date Nominated: July 31, 1997
Date Withdrawn: October 27, 1997
Reason: sexual misconduct allegations
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Name: Linda Chavez
Nominated by: George W. Bush
Nomination Position: Labor
Date Nominated: January 3, 2001
Date Withdrawn: January 9, 2001
Reason: undocumented household employee
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Name: Bernard Kerik
Nominated by: George W. Bush
Nomination Position: Homeland Security
Date Nominated: December 2, 2004
Date Withdrawn: December 10, 2004
Reason: undocumented household employee
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Name: Tom Daschle
Nominated by: Barack Obama
Nomination Position: Secretary of Health & Human Services
Date Nominated: December 11, 2008
Date Withdrawn: February 9, 2009
Reason: tax issues
Name: Zoe E. Baird
Nominated by: William J. Clinton
Nomination Position: Attorney General
Date Nominated: January 21, 1993
Date Withdrawn: January 26, 1993
Reason: Undocumented household employee
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Name: Anthony Lake
Nominated by: William J. Clinton
Nomination Position: Director, CIA
Date Nominated: January 9, 1997
Date Withdrawn: April 18, 1997
Reasons: policy disputes, financial issues
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Name: Hershel W. Gober
Nominated by: William J. Clinton
Nomination Position: Veterans Affairs
Date Nominated: July 31, 1997
Date Withdrawn: October 27, 1997
Reason: sexual misconduct allegations
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Name: Linda Chavez
Nominated by: George W. Bush
Nomination Position: Labor
Date Nominated: January 3, 2001
Date Withdrawn: January 9, 2001
Reason: undocumented household employee
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Name: Bernard Kerik
Nominated by: George W. Bush
Nomination Position: Homeland Security
Date Nominated: December 2, 2004
Date Withdrawn: December 10, 2004
Reason: undocumented household employee
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Name: Tom Daschle
Nominated by: Barack Obama
Nomination Position: Secretary of Health & Human Services
Date Nominated: December 11, 2008
Date Withdrawn: February 9, 2009
Reason: tax issues